CBD with Intelligent NanoDelivery SystemTM
• Full Spectrum ( max. 0,3% THC ) or Broad Spectrum ( 0% THC ) Hemp derived organic Oil.
• Concentrated formulas with other helpful ingredients • Ingredients nano-sized for better penetration.
• Stable in various base formulas.
• GMP quality control.
• Not tested on animals, Paraben-free, Eco-friendly.
Maoli Nano Sleep - 30ml ( Oil Soluble )
Nano Full Spectrum CannaBinoiDs 500mg (540mg real content) CBD, CBC, CBDV, CBG, CBN, Delta-9 THC Lipids,Surfactants,Fatty Acids
St. Johns Wort
Maoli Nano Sleep - 30ml
Magnesium, in order to fall asleep and stay asleep, your body and brain need to relax. On a chemical level, magnesium aids this process by activating the parasympathetic nervous system, the system responsible for getting you calm and relaxed.
Lavender, researchers monitored their sleep cycles with brain scans and found
that lavender increased slow-wave sleep, instrumental for slowing heartbeat and relaxing muscles. Subjects slept more soundly on the lavender night. The group also reported feeling more energetic the next morning.
Rosemary, may seem like an interesting herb to include in a sleep pillow, but it actually is a lovely addition. Unlike the previous herbs, rosemary actually helps you have vivid dreams. For many people, sleep ideally is a time to cope with our daily lives.
Melatonin, “Your body produces melatonin naturally. It doesn't make you sleep, but
as melatonin levels rise in the evening it puts you into a state of quiet wakefulness that helps promote sleep.
St. John's wort, some, but not all, research suggests that St. John's wort might reduce hot flashes. However, St. John's wort does not seem to improve sleep, quality of life, or other menopausal symptoms when used alone.
Cannabinoids, Preliminary research into cannabis and insomnia suggests that cannabidiol (CBD) may have therapeutic potential for the treatment of insomnia. Delta-9 tetrahydrocannabinol (THC) may decrease sleep latency but could impair sleep quality long-term. Novel studies investigating cannabinoids and obstructive sleep apnea suggest that synthetic cannabinoids such as nabilone and dronabinol may have short-term benefit for sleep apnea due to their modulatory effects on serotonin-mediated apneas. CBD may hold promise for REM sleep behavior disorder and excessive daytime sleepiness, while nabilone may reduce nightmares associated with PTSD and may improve sleep among patients with chronic pain. Research on cannabis and sleep is in its infancy and has yielded mixed results. Additional controlled and longitudinal research is critical to advance our understanding of research and clinical implications.
Why our patented Intelligent Nano delivery System?
The picture below shows how a hydrophilic molecule like CBD travels through the body. There are three reasons why the bioavailability may be less than expected. The first is that a person’s digestive system fails to break down droplets of CBD to a small enough level so the it can be absorbed by intestinal enterocytes. The reason could be poor stomach churning, poor juices from the liver or pancreas. The droplets of CBD remain large and pass right through. Even if the size reduction of droplets of CBD is good enough, if there is too much CBD, or too much of other fats and oils eaten at the same time, a bottleneck occurs and unabsorbed CBD moves on to the large intestine and out of your body. The third reason why CBD may be not bioavailable is that the Pancreatic Juice and Bile perform chemistry on the CBD and changes it into other compounds that may not have the same effectiveness.
The goal of nano-sizing CBD is two-fold. First it ensures that CBD exiting the stomach is as small as possible. Second, it protects the CBD from unwanted reactions caused by fluids from the Pancreas and Liver. Thus, more CBD in its original form is available for absorption. The bottleneck caused by excess fats and oils in the digestive system may still exist but there is more CBD available to start with.
The Pancreatic Juice and Bile are not all bad because they also contain compounds that can emulsify the CBD, called Bile salts. This emulsification is essential for absorption by microvilli at top of enterocytes that form the bumpy surface of the small intestine. These microvilli are covered with a layer of water that tend to prevent fats from touching the enterocyte surface and making contact with receptors that help the CBD get inside. By emulsifying
the CBD naturally with Bile salts your body is able to get fats past this water layer and to the enterocyte surface. There, the CBD is taken in and converted into a more complex Chylomicron. The Chylomicrons enter the lymph circulation which eventually drains into the blood stream. After moving around the body and releasing its CBD load, the Chylomicron body returns to the live where it is processed and filtered out.
Because the body has this process for oils and fats, there is no strong requirement to make nanoCBD as small as possible. The main need is to protect it from enzymatic degradation. The Bile salt emulsifiers will be produced in your body and will interact with the incoming nano-CBD, adjusting its size and surface characteristics so that it is ready for absorption and utilization.
What is more important is to be sure to take your CBD on an empty stomach to avoid any bottlenecks.
All about CannaBinoiDs
Hemp/Cannabis has been used by civilizations all over the world for
thousands of years. The history of this plant goes as far back as 12,000 B.C.E. Written language developed on hemp paper, the first woven clothes were made of hemp fiber, and modern medicine evolved from extractions of hemp flowers. CBD is non-psychoactive. Scientific and clinical research suggests CBD’s potential as a treatment for arthritis, diabetes, alcoholism, MS, chronic pain, schizophrenia, PTSD, depression, antibiotic-resistant infections, epilepsy, and otherneurological disorders.
How could CannaBinoiDs work?
The human body’s EndoCannabinoid System produces naturally occurring cannabinoids, Anadamide and 2-AG(2-atachidonoylglycerol), which stimulate the body’s
cannabinoid receptors. Cannabinoid receptors (CB1, CB2, TRPV1, TRPA1 and TRPV4) are present on multiple cell types in the human skin (fibroblasts, keratinocytes, immune cells, neurons, subcutaneous fat cells and muscle layers). These receptors engage in “retrograde signaling,” that inhibits immune response, reduces inflammation, relaxes muscles, lowers blood pressure, increases blood flow and normalizes over-stimulated nerves. In the epidermis, CBD inhibits keratinocyte proliferation, decreases keratinization and suppresses cornified envelope formation, promotes epidermal differentiation, and inhibits proliferation of keratinocytes. Studies have also shown CBD can improve reduced barrier function, increase hydration, reduce moisture loss, inhibit dermal fibrosis, suppress UV-B induced skin damage, and decrease inflammation.