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Maoli Sleep 300 mg CBD + 5 Terpenes + Melatonin

Maolicare Sleep/Relax

Full Spectrum CBD & melatonin for a more relaxed and natural sleep. 

Maolicare Sleep/Relax uses the same high quality full-spectrum hemp extracts from our own genetics as all our other products - but with an extra twist of 5 unique Terpenes and Melatonin.

Melatonin is a hormone produced naturally in the pineal gland from serotonin. Its task is to regulate the sleeping part of the sleep-wake cycle (circadian rhythm). 

For optimal Z's, add our recommended dosage to your herbal tea or drop it directly under the tongue before going to sleep or napping.

MaoliCare Sleep/Relax active ingredients in studies:

‘Beta’-Myrcene:

Myrcene is a monoterpene and an important precursor to many terpenes. It has a woody, vegetative, citrus, fruity, and mango-like scent. Myrcene is hypothesised to help compounds enter cells through enhancing membrane permeation. Myrcene has been shown to be an analgesic in mice and did not cause tolerance to the effect. Ther terpene is also noted to have antioxidant effects with mutagenic compounds. Another benefit to myrcene is its ability to relax muscles and induce sleep.

Sources - Myrcia, Bay Tree, Mango, Ylang-ylang, Wild Thyme, Parsley, Hops, Houttuynia, Verbena, Cannabis

Studies:
ANALGESIC
Oral administration of myrcene in rats was concluded to produce a dose-dependent pain relief for the hyperalgesia induced by subplantar injections of either carrageenin or prostaglandin E2, but did not affect that induced by dibutyryl cyclic AMP. These results indicated a peripheral site of action. In contrast to the central analgesic effect of morphine, myrcene did not cause tolerance on repeated dosing in rats. Myrcene shows promise as a lead for the development of new peripheral pain killers with a different method of action than aspirin-like drugs.

SEDATIVE

Myrcene was explored as a sedative in the mouse model. Muscle relaxation was seen as observed through the rota rod test. In addition there was an increase in sleeping time by 2.6x.

ANTIOXIDANT

Myrcene was eluted to block the metabolic activation of some promutagens (e.g., cyclophosphamide and aflatoxin B1) in in vitro genotoxicity assays. The effects of myrcene was evaluated through the activity of liver microsomes. A concentration-dependent competitive inhibition was observed for pentoxyresorufin -O-depenthylase activity, a selective marker for a cytochrome p450. The potent inhibitory effects on the cytochrome p450 suggest that myrcene, could also interfere with the metabolism of xenobiotics, which are substrates for this isoenzyme

Type of Terpene: Monoterpene

CAS: 123-25-3
FEMA No: 2762
Formula: C10H16
Molecular Mass: 136.23 g/mol Relative Density: 0.801g/mL
Water Solubility: 0.00109 g/L at 20 C Auto-ignition Temp: 255 C

Melting Point: < -80 C Boiling Point: 167 C
Flash Point: 44 C
LD50: > 5,000 mg/kg
Storage: 2 – 8 C, proper ventilation, spark proof environment.

Limonene:

Limonene has a strong citrus odor and flavor, the highest amounts are seen in citrus peels. Limonene is commonly used in perfume, house cleaners, food and medicine, partial due to it’s nice aroma and low toxicity. Limonene has been used as a house remedy for acne and athlete’s foot in the past.

Limonene has been shown to be a potent antidepressant and anti-anxiety treatment comparable to some traditional medicines. Limonene has also been inferred to be an anti- inflammatory, lowering or preventing key stages in the reaction. Limonene was elucidated in being a potential treatment for breast, prostate and pancreatic cancer.

Aroma – Citrus, orange, sweet, fresh Sources – Citrus, Cannabis

Studies:
ANTIDEPRESSANT/ANTI-ANXIETY
Limonene demonstrated increased social interaction time and decreased immobility time, in the forced swim test using mice, indicating anxiolytic and antidepressant effects. The effects were comparable with the traditional anxiolytic diazepam and the antidepressant fluoxetine.

ANTI-INFLAMMATORY

Limonene was evaluated against human eosinophilic leukemia cells, specifically looking at reactive oxygen species (ROS), monocyte chemoattractant protein-1 (MCP-1), nuclear factor (NF) kappa B, and p38 mitogen-activated protein kinase. Limonene was found to inhibit cytokine and ROS production, while inactivating eosinophil migration.

ANTI-CANCER

Limonene has been attributed to induction of phase I and phase II enzymes that result in carcinogen detoxification. In two prostate cancer cell lines, limonene administration resulted in higher ROS generation, depletion of GSH, accompanied by increased caspase. In addition limonene results in differentiation of cancer cells as well. Breast and pancreatic cancer cell lines were also negatively affected.

Type of Terpene: Monoterpene CAS: 5989-27-5
FEMA: 2633
Formula: C10H16

Molecular Mass: 136.23 g/mol
LD50: Mice > 5,500 mg/kg
Storage: 2 – 8 C, proper ventilation, spark proof environment Relative Density: 0.842 at 20 C
Melting Point: -74.3 C
Boiling Point: 176 C
Flash Point: 50 C

B-Caryophyllene:

Beta-caryophyllene is a sesquiterpene, with a sweet, woody, spicy, clove-like smell. It is a unique terpene due to its large size and structure. Due to these properties, beta- caryophyllene is able to activate several receptors in the body, including CB2, which is usually activated most by CBD. beta-caryophyllene has been shown to be an effective analgesic by regulating neuroinflammation and thermal hyperalgesia. Also as an antioxidant, beta-caryophyllene is effective as demonstrated by [preventing lipid oxidation and scavenging other radicals. As and anti-inflammatory beta-caryophyllene has been proven to mediate kidney inflammation and its side effects. In addition, beta-caryophyllene has been eluted to be a gastric-protective.

Aroma – Clove, Dry, Spicy, Sweet, Woody
Flavor – Spicy, Peppery, Woody, Camphoreous, Citrus

Studies:
ANALGESIC
The analgesic effects of beta-caryophyllene were evaluated in the rabbit conjunctival reflex test and in a rat phrenic nerve-hemidiaphragm preparation. Beta-caryophyllene attenuated thermal hyperalgesia and mechanical allodynia, and reduced spinal neuroinflammation. Also there were no signs of tolerance to the anti-hyperalgesic effects of BCP after prolonged treatment.

ANTI-OXIDANT

Beta-caryophyllene was demonstrated to have a high inhibitory capacity on lipid peroxidation and showed high scavenging activities against hydroxyl radicals and the superoxide anion.

ANTI-INFLAMMATORY

In kidney cells, beta- caryophyllene successfully ameliorated cisplatin-induced kidney dysfunction, morphological damage, and renal inflammatory response. The effect of the compound was also correlated to mitigate oxidative and nitrative stress.

GASTRIC-PROTECTIVE

Caryophyllene was indicated to significantly inhibit gastric mucosal injuries induced by necrotizing agents, yet barely affects the secretion of gastric acid and pepsin. Caryophyllene produced anti-inflammatory effects, without indication of gastric mucosal damage typical of non-steroidal anti-inflammatory agents like aspirin and ibuprofen.

Type of Terpene: Sesquiterpene CAS: 87-44-5
FEMA: 2252
Formula: C15H24

Molecular Mass: 204.35 g/mol
LD50: Rat – >5,000mg/kg
Storage: 2 – 8 C, proper ventilation, spark proof environment

Nerolidol:

Nerolidol is a sesquiterpene and that smells similar to fresh bark. There are two isomers present in nature, cis and trans. The terpene has been eluted to be a toxin against harmful protozoa like malaria and leishmaniasis. Furthermore, nerolidol is effect in delivering drugs through the skin.

Aroma - Citrus, Floral, Waxy, Woody
Sources - Neroli, Ginger, Jasmine, Lavender, Tea Tree, Lemon Grass, Cannabis

Studies:
TOPICAL DRUG ENHANCER
Nerolidol has been shown to help the passive skin penetration enhancement, helping a model hydrophobic permeant increase its absorption into skin by 20 fold. There were also significantly longer durations of action and did not wash off easily.
Cornwell PA, Barry BW (1994). Sesquiterpene components of
volatile oils as skin penetration enhancers for the hydrophilic
permeant 5-fluorouracil. J Pharm Pharmacol 46: 261–269.

ANTIPROTOZOAN

The research on nerolidol has concluded it to be a potent malaria drug. 100 microg/mL of nerolidol caused 100% of growth inhibition of young trophozoite to schizont stage after 48 hours of exposure. Nerolidol had an inhibitory effect on the biosynthesis of the isoprenic and dolichol side chains of the benzoquinon ring of ubiquinones in the organism. Thus the expression of p21 ras protein was significantly decreased.

Type of Terpene: Sesquiterpene Formula: C15H26O
Molecular Mass: 222.36 g/mol Relative Density: 0.875 g/mL

Water Solubility: 0.0141 g/L at 20 C Auto-ignition Temp: 255 C
Melting Point: -75 C
Boiling Point: 275 C

Flash Point: 96 C
LD50: > 5,000 mg/kg
Storage: Room temperature with proper ventilation, spark proof environment

Terpinolene:

Terpinolene is a common terpene primarily isolated from trees. It is present in high amounts in terpintine, which is used in the construction business as well. Terpinolene also goes by the name delta terpinene.
Terpinolene is not an analgesic or an anti-inflammatory, yet most cannabinoids and terpenoids are one of the two or both.
Terpinolene was concluded to be effective against several species of bacteria. Terpinolene is able to increase total antioxidant capacity levels in white blood cells without changing the total oxidative stress level. Terpinolene is further effective in fighting glial cell cancer and leukemia.

Sources - Apple, Cumin, Lilac, Tea Tree, Pine, Fir, Cannabis Aroma - Citrus, Fresh, Lemon, Piney, Sweet, Woody

Studies:
ANTIBACTERIAL
Terpinolene was elucidated to be toxic against, Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli through the disk susceptibility test minimum inhibitory concentrations measurements in a couple studies.

ANTI-OXIDANT

Genotoxic, oxidative and cytotoxic effects of terpinolene were explored with white blood cells. Genotoxicity was evaluated by micronucleus assay, sister chromatid exchanges assay, and 8-oxo-2-deoxyguanosine measurements. Cytotoxicity was detected by lactate dehydrogenase release and MTT assay. All assays were negative. Terpinolene treatment showed statistically significant increases of total antioxidant capacity levels in the cells without changing total oxidative stress levels. This antioxidant effect was also seen in preventing the oxidation of low density lipoprotein, which is helpful in combatting heart disease.

SEDATIVE

Nasal transmission of terpinolene was concluded to induce sleep in mice. Oral administration may prove more potent.

ANTI-CANCER

A key protein involved in progressing cancers, RAC-alpha serine/threonine-protein kinase, was shown to be reduced in leukemia cells with the treatment of terpinolene. Also brain cancer cells were shown to be significantly affected by the terpene as well, and no signs of genetic damage were seen in the normal cells.

INSECTICIDE

Terpinolene demonstrated toxic effects against cockroaches, Blattella germanica,through contact as well as a fumigant.
Type of Terpenes: Monoterpene
CAS: 586-62-9

FEMA No: 3046
Formula: C10H16
Molecular Mass: 136.23 g/mol
Relative Density: 0.861 g/cm3
Water Solubility: 9.5 mg/L at 25 C
Boiling Point: 184 C
Flash Point: 64 C
LD50: > 4,000 mg/kg
Storage: Room temperature, proper ventilation, spark proof environment.

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